Endocrine Abstracts

Introduction: CBG is the main transport protein for glucocorticoids in blood. CBG gene is a member of the serine protease inhibitor family, located at chromosome 14q32. Inherited CBG deficiency (MIM 611489) is a rarely recessive disorder, and the phenotype associated includes low cortisol levels, presence of normal ACTH levels, hypotension and fatigue, although the exact pathophysiological mechanisms involved remain uncertain. We identified a family with a complex phe...

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

Introduction: Generously supported by IPSEN)-->In children, GH secretion is considered sufficient when at least one value is >20 ng/ml at the GHRH + arginine (ARG) test. Because GH typically peaks at 45 min, we evaluated whether peak occurrence at one specific time is predictive of clinical outcomes in short stature children who are GH sufficient.Subjects and methods: Children who performed a GHRH plus ARG ...